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A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy.

Authors :
Cavalleri, Gianpiero L
Walley, Nicole
Soranzo, Nicole
Mulley, John C
Doherty, Colin P
Kapoor, Ashish
Depondt, Chantal
Lynch, John M
Scheffer, Ingrid E
Heils, Armin
Gehrmann, Anne
Kinirons, Peter
Gandhi, Sonia
Satishchandra, Parthasarathy
Wood, Nicholas W
Anand, Anuranjan
Sander, Thomas
Berkovic, S F
Delanty, Norman
Goldstein, David B
Sisodiya, Sanjay M
Cavalleri, Gianpiero L
Walley, Nicole
Soranzo, Nicole
Mulley, John C
Doherty, Colin P
Kapoor, Ashish
Depondt, Chantal
Lynch, John M
Scheffer, Ingrid E
Heils, Armin
Gehrmann, Anne
Kinirons, Peter
Gandhi, Sonia
Satishchandra, Parthasarathy
Wood, Nicholas W
Anand, Anuranjan
Sander, Thomas
Berkovic, S F
Delanty, Norman
Goldstein, David B
Sisodiya, Sanjay M
Source :
Epilepsia, 48 (4
Publication Year :
2007

Abstract

Although complex idiopathic generalized epilepsies (IGEs) are recognized to have a significant genetic component, as yet there are no known common susceptibility variants. It has recently been suggested that variation in the BRD2 gene confers increased risk of juvenile myoclonic epilepsy (JME), which accounts for around a quarter of all IGE. Here we examine the association between the candidate causal SNP (the promoter variant rs3918149) and JME in five independent cohorts comprising in total 531 JME cases and 1,390 healthy controls.<br />Comparative Study<br />Journal Article<br />Multicenter Study<br />Research Support, Non-U.S. Gov't<br />FLWIN<br />info:eu-repo/semantics/published

Details

Database :
OAIster
Journal :
Epilepsia, 48 (4
Notes :
1 full-text file(s): application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn803483370
Document Type :
Electronic Resource