A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx.

Authors :: Simmler, M C
Cunningham, D B
Clerc, P
Vermat, T
Caudron, B
Cruaud, C
Pawlak, A
Szpirer, Claude
Weissenbach, Jean
Claverie, J M
Avner, P
Simmler, M C
Cunningham, D B
Clerc, P
Vermat, T
Caudron, B
Cruaud, C
Pawlak, A
Szpirer, Claude
Weissenbach, Jean
Claverie, J M
Avner, P
Source :: Human molecular genetics, 5 (11
Publication Year :: 1996
Abstract: X chromosome inactivation in both mouse and human requires the presence of a cis acting locus, the X inactivation centre. This locus is thought to be involved in the initiation and spreading of the inactivation signal in early development. In order to increase our understanding of the mouse X inactivation centre, a 94 kb region immediately distal to the Xist gene has been sequenced and analysed for the presence of transcription units and/or potential cis acting regulatory elements. We have identified a novel gene, Tsx, lying 40 kb 3' from Xist. Tsx is expressed specifically in the testis and shows no convincing homology to proteins currently in the databases. A rat homologue, also X linked, has been isolated. The mouse and rat Tsx sequences are highly divergent, suggesting that part of the X inactivation centre, including both Xist and Tsx are subject to relatively weak evolutionary constraints.<br />Journal Article<br />Research Support, Non-U.S. Gov't<br />Research Support, U.S. Gov't, P.H.S.<br />info:eu-repo/semantics/published

Tools