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Gravity in mammalian organ development: differentiation of cultured lung and pancreas rudiments during spaceflight
- Source :
- The Journal of experimental zoology. 269(3)
- Publication Year :
- 1994
- Publisher :
- United States: NASA Center for Aerospace Information (CASI), 1994.
-
Abstract
- Organ culture of embryonic mouse lung and pancreas rudiments has been used to investigate development and differentiation, and to assess the effects of microgravity on culture differentiation, during orbital spaceflight of the shuttle Endeavour (mission STS-54). Lung rudiments continue to grow and branch during spaceflight, an initial result that should allow future detailed study of lung morphogenesis in microgravity. Cultured embryonic pancreas undergoes characteristic exocrine acinar tissue and endocrine islet tissue differentiation during spaceflight, and in ground controls. The rudiments developing in the microgravity environment of spaceflight appear to grow larger than their ground counterparts, and they may have differentiated more rapidly than controls, as judged by exocrine zymogen granule presence.
- Subjects :
- Life Sciences (General)
Subjects
Details
- Language :
- English
- ISSN :
- 0022104X
- Volume :
- 269
- Issue :
- 3
- Database :
- NASA Technical Reports
- Journal :
- The Journal of experimental zoology
- Publication Type :
- Report
- Accession number :
- edsnas.20050000331
- Document Type :
- Report
- Full Text :
- https://doi.org/10.1002/jez.1402690306