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Treatment of motion sickness in parabolic flight with buccal scopolamine

Authors :
Norfleet, William T
Degioanni, Joseph J
Reschke, Millard F
Bungo, Michael W
Kutyna, Frank A
Homick, Jerry L
Calkins, D. S
Source :
Aviation, Space, and Environmental Medicine. 63
Publication Year :
1992
Publisher :
United States: NASA Center for Aerospace Information (CASI), 1992.

Abstract

Treatment of acute motion sickness induced by parabolic flight with a preparation of scopolamine placed in the buccal pouch was investigated. Twenty-one subjects flew aboard a KC-135 aircraft operated by NASA which performed parabolic maneuvers resulting in periods of 0-g, 1-g, and 1.8-g. Each subject flew once with a tablet containing scopolamine and once with a placebo in a random order, crossover design. Signs and symptoms of motion sickness were systematically recorded during each parabola by an investigator who was blind to the content of the tablet. Compared with flights using placebo, flights with buccal scopolamine resulted in significantly lower scores for nausea (31-35 percent reduction) and vomiting (50 percent reduction in number of parabolas with vomiting). Side effects of the drug during flight were negligible. It is concluded that buccal scopolamine is more effective than a placebo in treating ongoing motion sickness.

Subjects

Subjects :
Aerospace Medicine

Details

Language :
English
ISSN :
00956562
Volume :
63
Database :
NASA Technical Reports
Journal :
Aviation, Space, and Environmental Medicine
Publication Type :
Report
Accession number :
edsnas.19920038094
Document Type :
Report