Back to Search Start Over

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Authors :
Kar, S. P.
Beesley, J.
Amin Al Olama, A.
Michailidou, K.
Tyrer, J.
Kote-Jarai, Z.
Lawrenson, K.
Lindstrom, S.
Ramus, S. J.
Thompson, D. J.
Kibel, Adam Stuart
Dansonka-Mieszkowska, A.
Michael, A.
Dieffenbach, A. K.
Gentry-Maharaj, A.
Whittemore, A. S.
Wolk, A.
Monteiro, A.
Peixoto, A.
Kierzek, A.
Cox, A.
Rudolph, A.
Gonzalez-Neira, A.
Wu, A. H.
Lindblom, A.
Swerdlow, A.
Ziogas, A.
Ekici, A. B.
Burwinkel, B.
Karlan, B. Y.
Nordestgaard, B. G.
Blomqvist, C.
Phelan, C.
McLean, C.
Pearce, C. L.
Vachon, C.
Cybulski, C.
Slavov, C.
Stegmaier, C.
Maier, C.
Ambrosone, C. B.
Hogdall, C. K.
Teerlink, C. C.
Kang, D.
Tessier, D. C.
Schaid, D. J.
Stram, D. O.
Cramer, Daniel William
Neal, D. E.
Eccles, D.
Flesch-Janys, D.
Edwards, D. R. V.
Wokozorczyk, D.
Levine, D. A.
Yannoukakos, D.
Sawyer, E. J.
Bandera, E. V.
Poole, Elizabeth M.
Goode, E. L.
Khusnutdinova, E.
Hogdall, E.
Song, F
Bruinsma, F.
Heitz, F.
Modugno, F.
Hamdy, F. C.
Wiklund, F.
Giles, G. G.
Olsson, H.
Wildiers, H.
Ulmer, H.-U.
Pandha, H.
Risch, H. A.
Darabi, H.
Salvesen, H. B.
Nevanlinna, H.
Gronberg, H.
Brenner, H.
Brauch, H.
Anton-Culver, H.
Song, H.
Lim, H.-Y.
McNeish, I.
Campbell, I.
Vergote, I.
Gronwald, J.
Lubinski, J.
Stanford, J. L.
Benitez, J.
Doherty, J. A.
Permuth, J. B.
Chang-Claude, J.
Donovan, J. L.
Dennis, J.
Schildkraut, J. M.
Schleutker, J.
Hopper, J. L.
Kupryjanczyk, J.
Park, J. Y.
Figueroa, J.
Clements, J. A.
Knight, J. A.
Peto, J.
Cunningham, J. M.
Pow-Sang, J.
Batra, J.
Czene, K.
Lu, K. H.
Herkommer, K.
Khaw, K.-T.
Matsuo, K.
Muir, K.
Offitt, K.
Chen, K.
Moysich, K. B.
Aittoma ki, K.
Odunsi, K.
Kiemeney, L. A.
Massuger, L. F. A. G.
Fitzgerald, L. M.
Cook, L. S.
Cannon-Albright, L.
Hooning, M. J.
Pike, M. C.
Bolla, M. K.
Luedeke, M.
Teixeira, M. R.
Goodman, M. T.
Schmidt, M. K.
Riggan, M.
Aly, M.
Rossing, M. A.
Beckmann, M. W.
Moisse, M.
Sanderson, M.
Southey, M. C.
Jones, M.
Lush, M.
Hildebrandt, M. A. T.
Hou, M.-F.
Schoemaker, M. J.
Garcia-Closas, M.
Bogdanova, N.
Rahman, N.
Le, N. D.
Orr, N.
Wentzensen, N.
Pashayan, N.
Peterlongo, P.
Guenel, P.
Brennan, P.
Paulo, P.
Webb, P. M.
Broberg, P.
Fasching, P. A.
Devilee, P.
Wang, Q.
Cai, Q.
Li, Q.
Kaneva, R.
Butzow, R.
Kopperud, R. K.
Schmutzler, R. K.
Stephenson, R. A.
MacInnis, R. J.
Hoover, R. N.
Winqvist, R.
Ness, R.
Milne, R. L.
Travis, R. C.
Benlloch, S.
Olson, S. H.
McDonnell, S. K.
Tworoger, Shelley Slate
Maia, S.
Berndt, S.
Lee, S. C.
Teo, S.-H.
Thibodeau, S. N.
Bojesen, S. E.
Gapstur, S. M.
Kjaer, S. K.
Pejovic, T.
Tammela, T. L. J.
Do rk, T.
Bru ning, T.
Wahlfors, T.
Key, T. J.
Edwards, T. L.
Menon, U.
Hamann, U.
Mitev, V.
Kosma, V.-M.
Setiawan, V. W.
Kristensen, V.
Arndt, V.
Vogel, W.
Zheng, W.
Sieh, W.
Blot, W. J.
Kluzniak, W.
Shu, X.-O.
Gao, Y.-T.
Schumacher, F.
Freedman, M. L.
Berchuck, A.
Dunning, A. M.
Simard, J.
Haiman, C. A.
Spurdle, A.
Sellers, T. A.
Hunter, David J.
Henderson, B. E.
Kraft, Peter Elias
Chanock, S. J.
Couch, F. J.
Hall, P.
Gayther, S. A.
Easton, D. F.
Chenevix-Trench, G.
Eeles, R.
Pharoah, P. D. P.
Lambrechts, D.
undefined, undefined
Source :
Quick submit: 2017-05-13T16:41:21-0400, Kar, S. P., J. Beesley, A. Amin Al Olama, K. Michailidou, J. Tyrer, Z. Kote-Jarai, K. Lawrenson, et al. 2016. “Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.” Cancer Discovery 6 (9) (July 17): 1052–1067. doi:10.1158/2159-8290.cd-15-1227.
Publication Year :
2016
Publisher :
American Association for Cancer Research (AACR), 2016.

Abstract

Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis.<br />Other Research Unit

Subjects

Subjects :
breast cancer
ovarian cancer
prostate cancer
genome-wide association studies
pleiotropy

Details

Language :
English
ISSN :
21598274
Database :
Digital Access to Scholarship at Harvard (DASH)
Journal :
Quick submit: 2017-05-13T16:41:21-0400, Kar, S. P., J. Beesley, A. Amin Al Olama, K. Michailidou, J. Tyrer, Z. Kote-Jarai, K. Lawrenson, et al. 2016. “Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.” Cancer Discovery 6 (9) (July 17): 1052–1067. doi:10.1158/2159-8290.cd-15-1227.
Publication Type :
Academic Journal
Accession number :
edshld.1.33840773
Document Type :
Journal Article
Full Text :
https://doi.org/10.1158/2159-8290.CD-15-1227
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details