Back to Search
Start Over
Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
- Source :
- Ritter, M. L., W. Guo, J. F. Samuels, Y. Wang, P. S. Nestadt, J. Krasnow, B. D. Greenberg, et al. 2017. “Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD).” Frontiers in Molecular Neuroscience 10 (1): 83. doi:10.3389/fnmol.2017.00083. http://dx.doi.org/10.3389/fnmol.2017.00083.
- Publication Year :
- 2017
- Publisher :
- Frontiers Media S.A., 2017.
-
Abstract
- Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.
- Subjects :
- ADHD
OCD
GWAS
meta-analysis
polygenic score
protein-protein link analysis
eQTL
Subjects
Details
- Language :
- English
- Database :
- Digital Access to Scholarship at Harvard (DASH)
- Journal :
- Ritter, M. L., W. Guo, J. F. Samuels, Y. Wang, P. S. Nestadt, J. Krasnow, B. D. Greenberg, et al. 2017. “Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD).” Frontiers in Molecular Neuroscience 10 (1): 83. doi:10.3389/fnmol.2017.00083. http://dx.doi.org/10.3389/fnmol.2017.00083.
- Publication Type :
- Academic Journal
- Accession number :
- edshld.1.32630603
- Document Type :
- Journal Article
- Full Text :
- https://doi.org/10.3389/fnmol.2017.00083