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Racial and ethnic variations in phthalate metabolite concentration changes across full-term pregnancies
- Source :
- James-Todd, Tamarra M, John D Meeker, Tianyi Huang, Russ Hauser, Ellen W Seely, Kelly K Ferguson, Janet W Rich-Edwards, and Thomas F McElrath. 2016. Racial and Ethnic Variations in Phthalate Metabolite Concentration Changes Across Full-Term Pregnancies. Journal of Exposure Science and Environmental Epidemiology (February 10). doi:10.1038/jes.2016.2. http://dx.doi.org/10.1038/jes.2016.2.
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- Higher concentrations of certain phthalate metabolites are associated with adverse reproductive and pregnancy outcomes, as well as poor infant/child health outcomes. In non-pregnant populations, phthalate metabolite concentrations vary by race/ethnicity. Few studies have documented racial/ethnic differences between phthalate metabolite concentrations at multiple time points across the full-course of pregnancy. The objective of the study was to characterize the change in phthalate metabolite concentrations by race/ethnicity across multiple pregnancy time points. Women were participants in a prospectively collected pregnancy cohort who delivered at term (≥37 weeks) and had available urinary phthalate metabolite concentrations for ≥ 3 time points across full-term pregnancies (n = 350 women). We assessed urinary concentrations of eight phthalate metabolites that were log-transformed and specific gravity-adjusted. We evaluated the potential racial/ethnic differences in phthalate metabolite concentrations at baseline (median 10 weeks gestation) using ANOVA and across pregnancy using linear mixed models to calculate the percent change and 95% confidence intervals adjusted for sociodemographic and lifestyle factors. Almost 30% of the population were non-Hispanic black or Hispanic. With the exception of mono-(3 carboxypropyl) (MCPP) and di-ethylhexyl phthalate (DEHP) metabolites, baseline levels of phthalate metabolites were significantly higher in non-whites (Po0.05). When evaluating patterns by race/ethnicity, mono-ethyl phthalate (MEP) and MCPP had significant percent changes across pregnancy. MEP was higher in Hispanics at baseline and decreased in mid-pregnancy but increased in late pregnancy for non-Hispanic blacks. MCPP was substantially higher in non-Hispanic blacks at baseline but decreased later in pregnancy. Across pregnancy, non-Hispanic black and Hispanic women had higher concentrations of certain phthalate metabolites. These differences may have implications for racial/ethnic differences in adverse pregnancy and child health outcomes.
Details
- Language :
- English
- ISSN :
- 15590631
- Database :
- Digital Access to Scholarship at Harvard (DASH)
- Journal :
- James-Todd, Tamarra M, John D Meeker, Tianyi Huang, Russ Hauser, Ellen W Seely, Kelly K Ferguson, Janet W Rich-Edwards, and Thomas F McElrath. 2016. Racial and Ethnic Variations in Phthalate Metabolite Concentration Changes Across Full-Term Pregnancies. Journal of Exposure Science and Environmental Epidemiology (February 10). doi:10.1038/jes.2016.2. http://dx.doi.org/10.1038/jes.2016.2.
- Publication Type :
- Academic Journal
- Accession number :
- edshld.1.29412073
- Document Type :
- Journal Article
- Full Text :
- https://doi.org/10.1038/jes.2016.2