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Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses
- Source :
- Okbay, A., B. M. Baselmans, J. De Neve, P. Turley, M. G. Nivard, M. A. Fontana, S. F. W. Meddens, et al. 2016. “Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses.” Nature genetics 48 (6): 624-633. doi:10.1038/ng.3552. http://dx.doi.org/10.1038/ng.3552.
- Publication Year :
- 2016
-
Abstract
- We conducted genome-wide association studies of three phenotypes: subjective well-being (N = 298,420), depressive symptoms (N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with subjective well-being, two with depressive symptoms, and eleven with neuroticism, including two inversion polymorphisms. The two depressive symptoms loci replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ̂| ≈ 0.8) strengthen the overall credibility of the findings, and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are strongly enriched for association.
Details
- Language :
- English
- ISSN :
- 10614036
- Database :
- Digital Access to Scholarship at Harvard (DASH)
- Journal :
- Okbay, A., B. M. Baselmans, J. De Neve, P. Turley, M. G. Nivard, M. A. Fontana, S. F. W. Meddens, et al. 2016. “Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses.” Nature genetics 48 (6): 624-633. doi:10.1038/ng.3552. http://dx.doi.org/10.1038/ng.3552.
- Publication Type :
- Academic Journal
- Accession number :
- edshld.1.29408364
- Document Type :
- Journal Article
- Full Text :
- https://doi.org/10.1038/ng.3552