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Characterizing genomic alterations in cancer by complementary functional associations
- Source :
- Kim, J. W., O. B. Botvinnik, O. Abudayyeh, C. Birger, J. Rosenbluh, Y. Shrestha, M. E. Abazeed, et al. 2016. “Characterizing genomic alterations in cancer by complementary functional associations.” Nature biotechnology 34 (5): 539-546. doi:10.1038/nbt.3527. http://dx.doi.org/10.1038/nbt.3527.
- Publication Year :
- 2016
-
Abstract
- Systematic efforts to sequence the cancer genome have identified large numbers of relevant mutations and copy number alterations in human cancers; however, elucidating their functional consequences, and their interactions to drive or maintain oncogenic states, is still a significant challenge. Here we introduce REVEALER, a computational method that identifies combinations of mutually exclusive genomic alterations correlated with functional phenotypes, such as the activation or gene-dependency of oncogenic pathways or the sensitivity to a drug treatment. We use REVEALER to uncover complementary genomic alterations associated with the transcriptional activation of β-catenin and NRF2, MEK-inhibitor sensitivity, and KRAS dependency. REVEALER successfully identified both known and new associations demonstrating the power of combining functional profiles with extensive characterization of genomic alterations in cancer genomes.
Details
- Language :
- English
- ISSN :
- 10870156
- Database :
- Digital Access to Scholarship at Harvard (DASH)
- Journal :
- Kim, J. W., O. B. Botvinnik, O. Abudayyeh, C. Birger, J. Rosenbluh, Y. Shrestha, M. E. Abazeed, et al. 2016. “Characterizing genomic alterations in cancer by complementary functional associations.” Nature biotechnology 34 (5): 539-546. doi:10.1038/nbt.3527. http://dx.doi.org/10.1038/nbt.3527.
- Publication Type :
- Academic Journal
- Accession number :
- edshld.1.29408333
- Document Type :
- Journal Article
- Full Text :
- https://doi.org/10.1038/nbt.3527