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Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition
- Source :
- Genetics. Jan, 2003, Vol. 163 Issue 1, p253, 14 p.
- Publication Year :
- 2003
-
Abstract
- We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population.
- Subjects :
- Genetic research -- Analysis
Chromosome mapping -- Genetic aspects
Population genetics -- Research
Chromosomes -- Genetic aspects
Gene expression -- Physiological aspects
Hormone receptors -- Genetic aspects
Hormone receptors -- Growth
Gene silencing -- Research
Company growth
Biological sciences
Subjects
Details
- ISSN :
- 00166731
- Volume :
- 163
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.98371147