Mutational analysis of roles for extracellular cysteine residues in the assembly and function of human alpha7-nicotinic acetylcholine receptors

Authors :: Dunkley, T.
Wu, J.
Zhao, L.
Lukas, R. J.
Source :: Biochemistry. Feb 4, 2003, Vol. 42 Issue 4, p870, 7 p.
Publication Year :: 2003
Abstract: Research has been conductsd on nicotinic acetylcholine receptors which contain alpha7 subunits. The hypothesis that functional expression of these receptors may be inhibited by the additional cysteine forming alternative disulfide bonds with the concerved cysteine of the disulfide loop has been tested, and the results are reported.

Subjects :: Biochemistry -- Research
Cysteine -- Genetic aspects
Cysteine -- Physiological aspects
Mutagenesis -- Usage
Nicotinic receptors -- Genetic aspects
Nicotinic receptors -- Physiological aspects
Chemical bonds -- Physiological aspects
Sulfides -- Physiological aspects
Biological sciences
Chemistry

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