Structural and thermodynamic studies on a salt-bridge triad in the NADP-binding domain of glutamate dehydrogenase from Thermotoga maritima: cooperativity and electrostatic contribution to stability

Authors :: Lebbink, Joyce H. G.
Consalvi, Valerio
Chiaraluce, Roberta
Berndt, Kurt D.
Ladenstein, Rudolf
Source :: Biochemistry. Dec 31, 2002, Vol. 41 Issue 52, p15524, 12 p.
Publication Year :: 2002
Abstract: Research has been conducted on hyperthermostable enzymes. The role of ion-pair networks in these enzymes has been investigated via the use of glutamate dehydrogenase, a model system from Thermotoga maritima, and the results are reported.

Subjects :: Biochemistry -- Research
Salts
Glutamate -- Physiological aspects
Oxidoreductases -- Physiological aspects
Electrostatics -- Research
Enzymes -- Physiological aspects
Biological sciences
Chemistry

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