Kinetic analysis of R67 dihydrofolate reductase folding: from the unfolded monomer to the native tetramer

Authors :: Bodenreider, Christophe
Kellershohn, Nicolas
Goldberg, Michel E.
Mejean, Annick
Source :: Biochemistry. Dec 17, 2002, Vol. 41 Issue 50, p14988, 12 p.
Publication Year :: 2002
Abstract: Research has been conducted on R67 dihydrofolate reductase. The study of the molecular steps involved in this reductase refolding and the search of the intermediates which could provide information on the folding mechanism are described.

Subjects :: Biochemistry -- Research
Chemical reaction, Rate of -- Research
Monomers -- Physiological aspects
Enzymes -- Physiological aspects
Protein folding -- Physiological aspects
Biological sciences
Chemistry

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