Solution structure and phosphopeptide binding to the N-terminal domain of Yersinia YopH: comparison with a crystal structure

Authors :: Khandelwal, Purnima
Keliikuli, Kai
Smith, Craig L.
Saper, Mark A.
Zuiderweg, Erik R.P.
Source :: Biochemistry. Sept 24, 2002, Vol. 41 Issue 38, p11425, 13 p.
Publication Year :: 2002
Abstract: The amino-terminal domain of Yersinia pseudotuberculosis tyrosine phosphatase YopH, is monomeric in solution with the phosphopeptide binding site on a beta-hairpin structure. Data indicate that the peptide binding does not induce any long-range conformational changes in YopH.

Subjects :: Yersinia -- Research
Tyrosine metabolism -- Physiological aspects
Conformational analysis
Protein binding -- Physiological aspects
Biological sciences
Chemistry

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