The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis

Research indicates that the HisZ and HisG proteins, constituents of the HisZG heteromeric ATP-phosphoribosyl transferase, exhibit a simple monomer-dimer structures, while the holoenzyme presents an octamer with four subunits each of HisZ and HisG. Furthermore, the sedimentation properties of the complex depend on the substrates and inhibitors present.