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Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2. (Reports)
- Source :
- Science. November 1, 2002, Vol. 298 Issue 5595, p1025, 5 p.
- Publication Year :
- 2002
-
Abstract
- β-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosai tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic ceil maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.<br />Activation of innate immunity through pattern recognition receptors for ligands derived from evolutionarily distant pathogens provides essential signals for initiation of the adaptive immune response (1-3). Microbial infection activates the [...]
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 298
- Issue :
- 5595
- Database :
- Gale General OneFile
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.94383594