Fe (super)2+ -tetracycline-mediated cleavage of the Tn10 tetracycline efflux protein TetA reveals a substrate binding site near glutamine 225 in transmembrane helix 7

Authors :: McMurry, Laura M.
Aldema-Ramos, Mila L.
Levy, Stuart B.
Source :: Journal of Bacteriology. Sept, 2002, Vol. 184 Issue 17-18, p5113, 8 p.
Publication Year :: 2002
Abstract: Research has been conducted on the TetA efflux pump protein. The study of the site where tetracyclin binds to this pump protein has been carried out and the results indicate that when chelated to tetracyclin Fe (super)2+ cleaves TetA backbone at glutamine 225 in transmembrane helix 7.

Subjects :: Bacteriology -- Research
Bacterial proteins -- Physiological aspects
Iron -- Physiological aspects
Tetracycline -- Physiological aspects
Glutamine -- Physiological aspects
Metal ions -- Physiological aspects
Biological sciences

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