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Modulation of the zinc(II) center in protein farnesyltransferase by mutagenesis of the zinc(II) ligands
- Source :
- Biochemistry. August 20, 2002, Vol. 41 Issue 33, p10554, 9 p.
- Publication Year :
- 2002
-
Abstract
- Research has been conducted on protein farnesyltransferase. The relationship between the zinc(II) center in this farnesyltransferase and the peptide thiolate reactivity alkylated by farnesyl diphosphate has been investigated and the results are presented.
- Subjects :
- Biochemistry -- Research
Ligands (Biochemistry) -- Genetic aspects
Zinc -- Physiological aspects
Proteins -- Physiological aspects
Mutagenesis -- Physiological aspects
Pyrophosphates -- Physiological aspects
Alkylation -- Physiological aspects
Peptides -- Physiological aspects
Metalloenzymes -- Physiological aspects
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 41
- Issue :
- 33
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.91032985