A new methodology for synthesis of a chiral phosphinocarboxylic acid through Michael cyclization-aldol tandem reaction of chiral alpha,beta,chi,psi-unsaturated bisphosphine oxide and application in palladium-catalyzed asymmetric allylic alkylation

Research has been conducted on the chiral alpha,beta,psi,omega-unsaturated bisphosphine oxide. Results indicate that after the treatment with lithium diisopropylamide and benzaldehyde this compound underwent Michael cyclization-aldol tandem reaction in producing endo-alpha,beta-unsaturated bisphosphine oxides.