Highly selective addition of chiral, sulfonimidoyl substituted bis(allyl)titanium complexes to N-sulfonyl alpha-imino esters: asymmetric synthesis of gamma,delta-unsaturated alpha-amino acids bearing a chiral, electron-withdrawing nucleofuge at the delta-position

Research demonstrates the highly selective addition of the bis(allyl)titanium complexes to alpha-imino esters to form (syn, E)-configured amino acids of different types and the synthesis of two new N-sulfonyl alpha-imino esters.