The aromatic 'trapping' of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase

Authors :: Barak, Dov
Kaplan, Dana
Ordentlich, Arie
Ariel, Naomi
Velan, Baruch
Shafferman, Avigdor
Source :: Biochemistry. July 2, 2002, Vol. 41 Issue 26, p8245, 8 p.
Publication Year :: 2002
Abstract: Research has been conducted on the catalytic histidine 447. The nature of the putitive array of interactions optimizing histidine 447 orientation has been explored and the details are reported.

Subjects :: Biochemistry -- Research
Aromatic compounds -- Physiological aspects
Histidine -- Physiological aspects
Catalysts -- Physiological aspects
Acetylcholinesterase -- Physiological aspects
Biological sciences
Chemistry

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