Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis

Authors :: Moore, Robert J.
Owens, David M.
Stamp, Gordon
Arnott, Caroline
Burke, Frances
East, Nick
Holdsworth, Hazel
Turner, Lynn
Rollins, Barrett
Pasparakis, Manolis
Kollias, George
Balkwill, Frances
Source :: Nature Medicine. July, 1999, Vol. 5 Issue 7, p828, 4 p.
Publication Year :: 1999
Abstract: Mice lacking in tumor necrosis factor-alpha (TNF-alpha), which is a pro-inflammatory cytokine, have been found to be resistant to skin carcinogenesis. Neutralizing TNF-alpha production is potentially useful in cancer treatment/prevention, but has little influence on later carcinogenesis stages.

Subjects :: Carcinogenesis -- Physiological aspects
Tumor necrosis factor -- Physiological aspects
Skin cancer -- Physiological aspects
Mice -- Physiological aspects
Cancer -- Prevention
Immunocytochemistry -- Research

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