Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors

Authors :: Lall, Manjinder S.
Ramtohul, Yeeman K.
James, Michael N. G.
Vederas, John C.
Source :: Journal of Organic Chemistry. March 8, 2002, Vol. 67 Issue 5, p1536, 12 p.
Publication Year :: 2002
Abstract: Research has been conducted on the hepatitis A virus 3C cysteine proteinase. The interaction of this proteinase with threonine and serine beta-lactones has been investigated and different inhibitory modes have been observed.

Subjects :: Chemistry, Organic -- Research
Serine -- Physiological aspects
Threonine -- Physiological aspects
Lactones -- Physiological aspects
Cysteine proteinases -- Physiological aspects
Chemical inhibitors -- Physiological aspects
Biological sciences
Chemistry

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