The utility of furan-, pyrrole-, and thiophene-based 2-silyloxy dienes as demonstrated by modular synthesis of annonaceous acetogenin core units and their pyrrolidine and thiolane analogues

Results point out that the utility and malleability of the vinylogous version of the Mukaiyama aldol and Mannich-type addition reactions with heterocyclic triad building modules for the synthesis of a repertoire of annonaceous acetogenin core units and their nitrogen and sulfur analogues.