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The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol

The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol

Authors :
Deeks, Emma D.
Cook, Jonathan P.
Day, Philip J.
Smith, Daniel C.
Roberts, Lynne M.
Lord, J. Michael
Source :
Biochemistry. March 12, 2002, Vol. 41 Issue 10, p3405, 9 p.
Publication Year :
2002

Abstract

Research has been conducted on the ricin A chain, protein toxins entering mammalian cells via endocytosis. The hypothesis that the lysine paucity reduces the chance of ubiquitination and ubiquitin-mediated proteasomal degradation has been investigated and the results are reported.

Details

ISSN :
00062960
Volume :
41
Issue :
10
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.84155146