Enantioselective synthesis of (2S,3R)-3-hydroxy-3-methylproline, a novel amino acid found in polyoxypeptins

Research has been conducted on the (2S,3R)-3-hydroxy-3-methylproline. The enantioselective synthesis of this compound has been carried out via the Sharpless AD reaction and the results indicate that the route has good enantiomeric purity and high yield.