Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons

Authors :: Jonghe, Steven de
Lamote, Inge
Venkataraman, Krishnan
Boldin, Swetlana A.
Hillaert, Ulrik
Rozenski, Jef
Hendrix, Chris
Busson, Roger
Keukeleire, Denis de
Calenbergh, Serge van
Futerman, Anthony H.
Herdewijn, Piet
Source :: Journal of Organic Chemistry. Feb 8, 2002, Vol. 67 Issue 3, p988, 9 p.
Publication Year :: 2002
Abstract: Research has been conducted on the D-erythro-homoceramide analogues. The synthesis of these analogues has been investigated and the results indicate that due to the lack of metabolism to glucosylhomoceramide none of the tested compounds have exhibited any biological activity.

Subjects :: Chemistry, Organic -- Research
Hippocampus (Brain) -- Physiological aspects
Neurons -- Growth
Sphingolipids -- Physiological aspects
Biological sciences
Chemistry

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