Pyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysis

Authors :: Herzberg, Osnat
Chen, Celia C.H.
Liu, Sijiu
Tempczyk, Aleksandra
Howard, Andrew
Wei, Min
Ye, Dongmei
Dunaway-Mariano, Debra
Source :: Biochemistry. Jan 22, 2002, Vol. 41 Issue 3, p780, 8 p.
Publication Year :: 2002
Abstract: Structural analysis of the enzyme-substrate complex reveals that phosphonopyruvate binds in the alpha/beta-barrel's central channel of the Beta-strands C-termini. The structure resembles that of pyruvate kinase but differes in the acid/base catalysis function.

Subjects :: Enzymes -- Structure-activity relationship
Binding sites (Biochemistry) -- Analysis
Crystals -- Structure
Protein kinases -- Research
Biological sciences
Chemistry

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