Characterization the corneal transparency profile in SMILE-treated myopic patients with densitometry: A 7-year cohort study

Purpose: To investigate 7-year changes in corneal densitometry (CD) and its influencing factors following small incision lenticule extraction (SMILE) for moderate to high myopia. Methods: A total of 32 patients (52 eyes) with a mean spherical equivalent (SE) refraction of -6.30 ± 1.30 D who underwent SMILE were recruited for this prospective study. Pre- and postoperative CD and corneal aberrations were measured by an oculus Pentacam system, and patients were followed up to 7 years. The CD evolution over time and its influencing factors were explored. Results: No complications were observed after SMILE. There was a significant time effect on postoperative CD (P < 0.05). The CD values at the 0-to-2 and 2-to-6 mm of the anterior layer increased at the first day (P < 0.05) and declined to baselines at 1 year postoperatively; after that, CD values at any zone and any corneal layer presented a decreasing trend over time (all P < 0.05). Multivariate analysis showed that postoperative CD was positively correlated with age and optical zone (OZ), whereas negatively correlated with SE, corrected distance visual acuity (CDVA), and corneal aberrations (higher-order aberrations, Coma0 and Coma90) (all P < 0.05). Generalized estimating equation revealed that age, SE, CDVA, OZ, and Coma0 were the main factors influencing postoperative CD values (all P < 0.05). Conclusion: CD manifested a long-term decreasing trend in moderate to high myopia treated with SMILE. Its main influencing factors are age, SE, CDVA, OZ, and Coma0. Keywords: Corneal densitometry, myopia, small incision lenticule extraction
Author(s): Dongmei Yang [1,2,3,6]; Zhuoyi Chen [1,2,3]; Wuxiao Zhao [1,2,3,4]; Jing Zhao [1,2,3]; Xingtao Zhou (corresponding author) [1,2,3]; Jifang Wang (corresponding author) [1,2,3,5] Corneal transparency is a key element of [...]