Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

The mucosa-associated lymphoid tissue protein Bcl10, containing an N-terminal caspase recruitment domain, regulates lymphocyte proliferation, connecting antigen receptor signaling in B and T lymphocytes to NF-kappaB activation. Data point out that Bcl10 is also involved in neural tube closure.