E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Authors :: Porse, Bo T.
Pedersen, Thomas A.
Xu, Xiufeng
Lindberg, Bo
Wewer, Ulla M.
Friis-Hansen, Lennart
Nerlov, Claus
Source :: Cell. Oct 19, 2001, Vol. 107 Issue 2, p247, 12 p.
Publication Year :: 2001
Abstract: Results show that differentiation of adipocytes and neutrophil granulocytes and their proliferation is controlled by the transcription factor C/EBPalpha, which represses E2F. C/EBPalpha mutants defective in E2F repression activity are unable to suppress cellular proliferation.

Subjects :: Adipose tissues -- Physiological aspects
Granulocytes -- Physiological aspects
Neutrophils -- Physiological aspects
Cell proliferation -- Physiological aspects
Biological sciences

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