BIG: a calossin-like protein required for polar auxin transport in Arabidopsis

Research has shown that doc1 mutants are allelic to tir3 mutants and that they define BIG, a calossin-like protein necessary for Arabidopsis polar auxin transport. The BIG gene, which is very large, giving a reason for the name, likely encodes an enormous protein with significant identity to the Drosophila protein Calossin/Pushover.