The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress

The loop domain of heat shock transcription factor (HSF) 1 has been found to determine DNA-binding specificity and heat stress responses. The mechanistic basis for differences between HSF1 and HSF2 in DNA binding to the hsp70 heat shock elements (HSEs) and its effect on transcription has been studied. HSPs are heat shock proteins.