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Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain

Authors :
Nalefski, Eric A.
Newton, Alexandra C.
Source :
Biochemistry. Nov 6, 2001, Vol. 40 Issue 44, p13216, 14 p.
Publication Year :
2001

Abstract

Association and dissociation kinetics of the membrane binding by the isolated C2 domain of protein kinase C beta and the full-length enzyme betaII reveal that calcium targets the enzyme via the C2 domain, which triggers C1 domain to search for the secon messenger diacylglycerol.

Details

ISSN :
00062960
Volume :
40
Issue :
44
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.80384516