Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. (Brief Genetics Report)

Authors :: del Giudice, Emanuele Miraglia
Santoro, Nicola
Cirillo, Grazia
D'Urso, Luigi
Di Toro, Rosario
Perrone, Laura
Source :: Diabetes. September 2001, Vol. 50 Issue 9, p2157, 4 p.
Publication Year :: 2001
Abstract: Cocaine- and amphetamine-regulated transcript (CART) inhibits feeding and induces the expression of c-Fos in hypothalamic areas implicated in appetite regulation. Furthermore, the CART peptide is found in neurons regulating sympathetic [...]

Subjects :: Gene mutations -- Research -- Genetic aspects
Obesity in children -- Genetic aspects -- Research
Phenotype -- Evaluation -- Research -- Genetic aspects
Peptides -- Evaluation -- Genetic aspects -- Research
Health
Evaluation
Research
Genetic aspects

Tools