Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors

Authors :: Gaus, Katharina
Dean, Roger T.
Kritharides, Leonard
Jessup, Wendy
Source :: Biochemistry. Oct 30, 2001, Vol. 40 Issue 43, p13002, 13 p.
Publication Year :: 2001
Abstract: Research demonstrates that 7-ketocholesterol inhibits cholesterol efflux in all cellular systems studied. Data suggest that the structure of 7-ketocholesterol and its effect on the membrane lipid composition may be the key regulatory elements influencing its action.

Subjects :: Cholesterol -- Physiological aspects
Biological transport -- Physiological aspects
Structure-activity relationships (Biochemistry) -- Analysis
Membrane lipids -- Physiological aspects
Biological sciences
Chemistry

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