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The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation
- Source :
- Biochemistry. Sept 11, 2001, Vol. 40 Issue 36, p10901, 10 p.
- Publication Year :
- 2001
-
Abstract
- Research has been conducted on the polycyclic aromatic hydrocarbons. These hydrocarbons have been metabolized to trans-dihydrodiols proximate carcinogens by human epoxide hydrolase and CYP1A1 and the results are discussed.
- Subjects :
- Biochemistry -- Research
Aldehydes -- Physiological aspects
Oxidation-reduction reaction -- Physiological aspects
Carcinogens -- Physiological aspects
Quinone -- Physiological aspects
Hydrocarbons -- Physiological aspects
Aromatic compounds -- Physiological aspects
Epoxy compounds -- Physiological aspects
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 40
- Issue :
- 36
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.78925216