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Neuroendocrine and renal effects of intravascular volume expansion in compensated heart failure
- Source :
- The American Journal of Physiology. August, 2001, Vol. 281 Issue 2, R459
- Publication Year :
- 2001
-
Abstract
- To examine if the neuroendocrine link between volume sensing and renal function is preserved in compensated chronic heart failure [HF, ejection fraction 0.29 [+ or -] 0.03 (mean [+ or -] SE)] we tested the hypothesis that intravascular and central blood volume expansion by 3 h of water immersion (WI) elicits a natriuresis. In HF, WI suppressed ANG II and aldosterone (Aldo) concentrations, increased the release of atrial natriuretic peptide (ANP), and elicited a natriuresis (P [is less than] 0.05 for all) compared with seated control. Compared with control subjects (n = 9), ANG II, Aldo, and ANP concentrations were increased (P [is less than] 0.05) in HF, whereas absolute and fractional sodium excretion rates were attenuated [47 [+ or -] 16 vs. 88 [+ or -] 15 [micro]mol/min and 0.42 [+ or -] 0.18 vs. 0.68 [+ or -] 0.12% (mean [+ or -] SE), respectively, both P [is less than] 0.05]. When ANG II and Aldo concentrations were further suppressed (P [is less than] 0.05) during WI in HF (by sustained angiotensin-converting enzyme inhibitor therapy, n = 9) absolute and fractional sodium excretion increased (P [is less than] 0.05) to the level of control subjects (108 [+ or -] 34 [micro]mol/min and 0.70 [+ or -] 0.23%, respectively). Renal free water clearance increased during WI in control subjects but not in HF, albeit plasma vasopressin concentrations were similar in the two groups. In conclusion, the neuroendocrine link between volume sensing and renal sodium excretion is preserved in compensated HF. The natriuresis of WI is, however, modulated by the prevailing ANG II and Aldo concentrations. In contrast, renal free water clearance is attenuated in response to volume expansion in compensated HF despite normalized plasma AVP concentrations. renin-angiotensin system; aldosterone; vasopressin; waterelectrolyte balance
Details
- ISSN :
- 00029513
- Volume :
- 281
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.78030691