Detection of disulfide bonds in bovine brain tubulin and their role in protein folding and microtubule assembly in vitro: a novel disulfide detection approach

Research has been conducted on the tubulin cysteine residues involved in regulating ligand interactions and microtubule formation. Results indicate that oxidized state of tubulin is responsible for the specific chaperone-assisted refolding and that the oxidation or reduction of the cell status can be a critical factor for microtubule assemble regulation.