Profiling Metal-Induced Genotoxic Endpoints

Many toxic metals are involved in the initiation and progression of DNA damage that can result in the activation of DNA damage response machinery at double--and single-stranded DNA; this response can result in global and gene-specific DNA alteration. The toxicological profiles from the Agency for Toxic Substances and Disease Registry (ATSDR) and several other studies have demonstrated the influence of metal exposure- induced genotoxic endpoints and epigenetic modifications. Our review systematically summarizes accumulating evidence from ATSDR toxicological profiles and the available literature that demonstrate a possible induction of various genotoxic endpoints and metal exposures. We include in this article studies on chromium, arsenic, nickel, lead, mercury, and zinc.
Introduction This article compiles information from several of the Agency for Toxic Substances and Disease Registry (ATSDR) toxicological profiles to summarize genotoxic endpoints associated with exposure to metals. Humans are [...]