Evidence that familial hypercholesterolemia mutations of the LDL receptor cause limited local misfolding in an LDL-A module pair

Research has been conducted on the mutations within the ligand-binding low-density lipoprotein (LDL) -A modules of the LDL receptor. The impact of two familial hypercholesterolemia mutations in the LDL-A module five and two mutations in module six has been investigated.