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Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes

Authors :
Arndt, Joseph W.
Gong, Weimin
Zhong, Xuejun
Showalter, Alexander K.
Liu, Jia
Dunlap, Christopher A.
Lin, Zheng
Paxson, Chad
Tsai, Ming-Daw
Chan, Michael K.
Source :
Biochemistry. May 8, 2001, Vol. 40 Issue 18, p5368, 8 p.
Publication Year :
2001

Abstract

Research on an intermediate structure of DNA polymerase beta shows that there is no rate-limiting step during conformational change. This enzyme has two metal-binding sites, one at the dNTP binding site and one at the catalytic site.

Details

ISSN :
00062960
Volume :
40
Issue :
18
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.76160592