Total synthesis and determination of the absolute configuration of frondosin

Authors :: Inoue, Masayuki
Carson, Matthew W.
Frontier, Alison J.
Danishefsky, Samuel J.
Source :: Journal of the American Chemical Society. March 7, 2001, Vol. 123 Issue 9, p1878, 1 p.
Publication Year :: 2001
Abstract: It has been possible to obtain two concise syntheses of the interleukin-8 receptor antagonist (+/-)-frondosin B from commercially available 5-methoxysalicylaldehyde. The absolute configuration of the secondary methyl centre in frondosin B was established as R.