The nuclear receptor subfamily 4 group Al in human disease

Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator in a wide range of signaling pathways and responses to human diseases. Here, we provide a brief overview of the current functions of NR4A1 in human diseases and the factors involved in its function. A deeper understanding of these mechanisms can potentially improve drug development and disease therapy. Key words: NR4A1, function, human disease, molecular pathway
1. Introduction The nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, contains three members: NR4A1 (mouse homologue Nur77, rat homologue NGFI-B, and human homologue TR3 [...]