WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo

Authors :: Kawakami, Yasuhiko
Capdevila, Javier
Buscher, Dirk
Itoh, Tohru
Rodriguez Esteban, Concepcion
Izpixua Belmonte, Juan Carlos
Source :: Cell. March 23, 2001, Vol. 104 Issue 6, p891, 10 p.
Publication Year :: 2001
Abstract: Three WNT factors have been shown to signal through beta-catenin function as critical regulators of the FGF-8/FGF-10 loop. Induction of Fgf-8 in the limb ectoderm by FGF-10 is mediated by the induction of Wnt-a. Three WNT signals mediated by beta-catenin control both limb initiation and apical ectodermal ridge (AER) induction in the vertebrate embryo.

Subjects :: Cytochemistry -- Research
Embryology, Experimental -- Research
Extremities (Anatomy) -- Genetic aspects
Ectoderm -- Genetic aspects
Chick embryo -- Genetic aspects
Cellular signal transduction -- Research
Biological sciences

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