The role of the ubiquitin‐proteasome pathway in rhTRIM5α restriction of HIV‐1

16‐17 July 2010, International AIDS Society’s Workshop “Towards a Cure”: HIV Reservoirs and Strategies to Control Them, Vienna, Austria
Background rhTRIM5α is a restriction factor that blocks HIV‐1 infection by interacting with the capsid core early after entry. Although rhTRIM5α blocks accumulation of reverse transcription products, proteasome inhibitors rescue [...]