Selective Voltammetric and Flow-Injection Amperometric Determination of Acyclovir and Valacyclovir on an Electrode with a Reduced Graphene Oxide-Polyglycine Film Composite

Acyclovir and valacyclovir are oxidized on a glassy carbon electrode (GCE) with immobilized reduced graphene oxide coated with a polyglycine film. We selected the conditions for forming a polymer film, reducing graphene oxide on the GCE, and recording the maximum catalytic current on the composite surface. A procedure was developed for the selective voltammetric determination of acyclovir and valacyclovir on an electrode with a reduced graphene oxide-polyglycine film composite. A method is proposed for the amperometric detection of guanine-based antiviral drugs with this modified electrode under the conditions of flow-injection analysis. The dependence of the analytical signal on the concentration of acyclovir and valacyclovir is linear up to 5 x 10.sup.-6 M in the static mode and up to 1 x 10.sup.-7 M in the flow-injection system. The developed voltammetric method for determining acyclovir and valacyclovir was tested in the analysis of pharmaceutical preparations.
Author(s): L. G. Shaidarova [sup.1] , A. V. Gedmina [sup.1] , A. A. Poadnyak [sup.1] , I. A. Chelnokova [sup.1] , H. C. Budnikov [sup.1] Author Affiliations: (1) grid.77268.3c, 0000 [...]