RNA-catalyzed CoA, NAD, and FAD synthesis from phosphopantetheine, NMN, and FMN

Research addresses the origin and evolution of coenzymes as exemplified by their synthesis and utilization in the RNA world. Data point out that two RNA sequences with coenzyme-synthesizing activities can mediate the synthesis of coenzyme A, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide from their precursors.