Leprosy in wild chimpanzees

Humans are considered as the main host for Mycobacterium leprae.sup.1, the aetiological agent of leprosy, but spillover has occurred to other mammals that are now maintenance hosts, such as nine-banded armadillos and red squirrels.sup.2,3. Although naturally acquired leprosy has also been described in captive nonhuman primates.sup.4-7, the exact origins of infection remain unclear. Here we describe leprosy-like lesions in two wild populations of western chimpanzees (Pan troglodytes verus) in Cantanhez National Park, Guinea-Bissau and Taï National Park, Côte d'Ivoire, West Africa. Longitudinal monitoring of both populations revealed the progression of disease symptoms compatible with advanced leprosy. Screening of faecal and necropsy samples confirmed the presence of M. leprae as the causative agent at each site and phylogenomic comparisons with other strains from humans and other animals show that the chimpanzee strains belong to different and rare genotypes (4N/O and 2F). These findings suggest that M. leprae may be circulating in more wild animals than suspected, either as a result of exposure to humans or other unknown environmental sources. Monitoring of western chimpanzee populations in Guinea-Bissau and Côte d'Ivoire reveals the presence of rare and different genotypes of Mycobacterium leprae, suggesting greater circulation in wild animals than previously thought.
Author(s): Kimberley J. Hockings [sup.1] [sup.2] , Benjamin Mubemba [sup.3] [sup.4] , Charlotte Avanzi [sup.5] [sup.6] [sup.7] [sup.8] , Kamilla Pleh [sup.3] [sup.9] , Ariane Düx [sup.3] , Elena Bersacola [...]