Profilin 1 Protein and Its Implications for Cancers

Profilin 1 (PFN1) is a key actin-binding protein that is involved in various cellular activities, such as cell motility, survival, and membrane trafficking. Dysfunction of PFN1 is associated with many diseases, including amyotrophic lateral sclerosis, hypertension, and cancer. Recent studies have confirmed the critical roles of PFN1 in tumorigenesis, metastasis, proliferation, and drug resistance. However, the roles of PFN1 in cancers vary among cancer types and even appear contrasting in the same cancer type in different studies. Here, we review the functions of PFN1 in cancers and discuss its potential future clinical applications. By summarizing the functions of PFN1 in cancer, we hope to better understand the mechanisms of PFN1 in cancer progression. KEY WORDS: profilin 1; cancer; biomarker; function
Introduction Profilin 1 (PFN1) is a ubiquitous small-molecule protein that exists in all eukaryotes. (1) PFN1 was irst identiied as a G-actin sequestering molecule, (2) and subsequently, its true functions [...]